Tissue inflammation and the Langerhans cell histiocytosis lesion
Eradicating the neoplastic clone
Neurodegeneration in LCH
Immune Strategies in the Histiocytoses
Myeloid Cell Programming and Differentiation
LCH: The Cell of Origin and a Pathway to a Rationale Cure
Mechanisms of Resistance and Therapeutic Development
Mechanisms and Long term Consequences of Neuroinflammatory Disease
Harnessing Immunology and Inflammation in Neoplasms: Relevance to LCH and Histiocytic Disorders
Cellular Origins of Dendritic CelΙs: Implications for LCH
Cell Signaling and Responses: Pathways to Cure?
Genomics and Metabolomics in Dendritic Cells: Are there clues for LCH causes and cures?
Mechanisms and therapeutic targets of inflammatory disease of the CNS
Viral, autoimmune and neoplastic mechanisms of granuloma formation and possible relevance to LCH
The tolerogenic nature of tumor-associated inflammation: relevance for LCH
Langerhans Cell Function: Implications for LCH
A hematopoietic stem cell disorder?
Dendritic cell plasticity
Langerhans cell histiocytosis: Bystander cells, interactions, pathophysiology
Langerhans cell histiocytosis: neoplasia or immune dysregulation?
Proceedings by Dr Kim Nichols: Click Here.
Dendritic cell differentiation: Signals, signalling and functional consequences: Clues to possible therapy.
Analysis of the functional consequences of aberrant antigen expression.
Acute and chronic cytokine networks leading to tissue damage.
Dendritic cells and the brain in LCH.
Genetics and animal models of Langerhans Cell Histiocytosis (LCH). Identified the need for animal models
Migration and in vivo interactions of immune cells. Led to work on chemokines
Apoptosis in LCH. Stimulated work on the cell cycle and survival
Cell biology and molecular biology in LCH. Discussed dendritic-cell differentiation and cell survival and death.
Langerhans cell histiocytosis therapeutics present and future. Stimulated use of antibodies for localization and treatment of disease
The neuropathology and pharmacology of LCH. Led to long-term studies of neurological and psychosocial aspects of the disease
The role of cytokines in LCH. Stimulated much work on cytokines
Viruses as a possible trigger in LCH – developing a strategy. No evidence for viral aetiology
LCH – an immunological disease? Identified avenues for future research and the importance of determining clonality
